Monday, November 29, 2021

Where Do We Draw the Line?: Psychiatric Patient Autonomy

    My sophomore year I took two classes called “Philosophy of Mental Health” and “Drugs and Society”, in which we discussed an important ethical issue of patient autonomy and their right to refuse treatment. An interesting story in one of the required readings was about a college boy who experienced a psychotic break and broke into a family’s home to take a bath. After the police detained him and he was eventually brought to the hospital, the boy refused all treatment and demanded to leave despite the doctor and his parents pleading for him to get the help he obviously needed. Ultimately, he was allowed to leave unmedicated and untreated (although the boy was sued later on for trespassing). As college students we rarely experience or hear of stories like this, but it made me question what lines and regulations should allow doctors to virtuously overrule patients that refuse treatment they need? What would I have done if I was the doctor?

    While the majority of psychiatrists hold their patient’s wellbeing at the highest of their priorities, an ethics dilemma that has been at the forefront of psychiatric care for years is the need of boundaries and framework to override patient autonomy if intervention is deemed necessary. Primarily, a patient’s diagnosis or mental incapacity is usually relied on as justification for these decisions, but this is an obvious violation of rights for people with mental disabilities if the foundation of these claims is not supported. So, what ultimately decides these two criteria for overriding patient autonomy? For the diagnostic lens, many people have considered physiologic biomarkers and epistemic irrationality as indicators. However, these measures are not always reliable as epistemic irrationality is commonly used hastily to diagnose untreated patients despite the possibility of mental disorder and epistemic irrationality being exclusively mutual from each other. Biomarkers similarly are not always constant across every mental disorder. Therefore, biomarkers and epistemic irrationality cannot be means of reason for intervention in the health of psychiatric patients. 

    Currently, the mental incapacity criteria for intervention is the favored approach as it focuses on decision-making capabilities of the individual and incorporates the patients’ autonomy into the equation. The only challenge with this is where to draw the line and how to baseline mental incapacity, as neurodiversity creates an uneven playing field for defining “normal” and “rational” thought/behavior. A better model that has been proposed (and I believe to be fairer) is defining mental incapacity by statistical normality, although there are holes that are left uncovered as well. Ultimately, this issue remains open-ended, which I fear a ”silver bullet” model will never be found as there are only advantages and disadvantages for every proposed solution to get people the treatment they need while keeping their autonomy intact. 

 

Craigie, J., & Bortolotti, L. (2015). Rationality, diagnosis, and patient autonomy in psychiatry. In 

J. Z. Sadler, W. (C. W. . van Staden, & K. W. M. Fulford (Eds.), The Oxford handbook of psychiatric ethics., Vol. 1. (pp. 387–404). Oxford University Press.

Is gene therapy the future?

 


Should one use a study drug?

            Have you ever questioned your ability to finish everything at top quality in time? Have you ever complained to your friends about your workload? If so, then chances are someone has suggested you take some sort of study drug to help you focus or work more efficiently. Various forms of study drugs have been taken by students to increase academic performance for years. In Australia, university faculty responses have been rather lax and more focused on student health instead of a potential integrity violation (Dunn et al., 2020). According to Dunn et al. (2020), the university setting may promote the use of study drugs to meet requirements and deadlines by increasing study stamina and focus.

Dunn et al. (2020) surveyed 14 faculty members, institutional department heads or support roles. During this study, the researchers questioned if the faculty knew study drugs were being used and if they would deem it as cheating. Their consensus indicated knowledge of study drug usage however, many argued that they would not deem usage as cheating. With this in mind, is study drug a problem that should be considered cheating? Should it be discouraged, or individuals penalized for usage?

Personally, I lean more to the “as long as they learn the material” viewpoint. Sure, one can argue that such drug usage provides an unfair advantage in an already tilted education system. In that regard, the counterpoint is that study drugs also offer a benefit to those who are “impaired” (i.e. diagnosed with ADHD and its variants or LD). What makes a study drug less acceptable than caffeine? Almost every student I know has consumed exorbitant amounts of caffeine in their study sessions around finals or midterms. Mazanov et al. (2013) surveyed almost 1800 students in which about 86% used caffeine to enhance study performance. Is caffeine abuse worse than Adderall? Similarly, other drugs such as SSRI, SNRI, anti-anxiety medication and psychostimulants have seen increased usage over the years (Morris et al., 2021). Should all focus psychoactive drugs be barred? Should those students be denied their prescriptions in the case of fairness? The threat of abuse with study drugs is real and should be addressed in another blog. But if a student learns the material, should they be looked down upon or disciplinary action be taken if an individual is taking a study drug?

 

Dunn, M., Dawson, P., Bearman, M., & Tai, J. (2020). ‘I’d struggle to see it as cheating’: The policy and regulatory environments of study drug use at universities. Higher Education Research & Development, 40(2), 234–246. https://doi.org/10.1080/07294360.2020.1738351

Mazanov, J.Dunn, M.Connor, J., & Fielding, M.-L. (2013). Substance use to enhance academic performance among Australian university studentsPerformance Enhancement & Health2(3), 110118. doi: 10.1016/j.peh.2013.08.017

Morris, M. R., Hoeflich, C. C., Nutley, S., Ellingrod, V. L., Riba, M. B., & Striley, C. W. (2021). Use of psychiatric medication by college students: A decade of data. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy41(4), 350. https://doi-org.dml.regis.edu/10.1002/phar.2513

Aortic Stenosis Treatment for Cancer Patients


Aortic stenosis is caused by a buildup of calcium deposits in the heart valve. Excessive buildup can cause narrowing of the heart valve, a decrease in blood pressure, and can lead to heart failure (Lopez-Jimenez, M.D., 2021). The most effective treatment for this disease is surgical valve replacement. However, this procedure poses great risk to a patient with active cancer in the area. The complications that could incur from undergoing this procedure would likely lead to infections and excessive bleeding (Bendary, et. al., 2020). Other treatments, such as angiotensin-converting enzyme inhibitors and beta blockers, have been used but patients typically die within a few years because the treatments are too conservative (Kornowski, Landes 2018). The aortic valve replacement procedure is intrusive, exposing the cancer patient to high-risk complications, on the other hand, medications have been found to be not aggressive enough, leading to death of the patient. 

An alternative treatment method has been tested, called TAVR. This is a transcatheter aortic valve replacement treatment, which is less intrusive than an open-heart valve replacement (Henry Ford Health System Staff, 2019). A cancer patient would be an ideal person to receive this type of treatment because of reduced intrusiveness of the procedure. The use of this treatment on cancer patients has yet to be deemed safe and reliable (Marmagkiolis et. al., 2021). After surgery, cancer patients undergoing this type of treatment have been found to have a worse 1-year prognosis when compared to their non-cancer counterparts (Landes, 2019) A study published by the Journal of the American College of Cardiology states that cancer patients have a decreased long-term life expectancy compared to their non-cancer counterparts after undergoing this procedure (Lind, et. al., 2020). Without understanding the effectiveness, safety, and reliability of this treatment, is it ethical for cancer patients to have this procedure? Is there enough evidence supporting the long-term benefits of this procedure to allow cancer patients to face potential risks? 

References: 

Bendary, A., Ramzy, A., Bendary, M., & Salem, M. (2020, March 11). Transcatheter aortic valve replacement in patients with severe aortic stenosis and active cancer: A systematic review and meta-analysis. US National Library of Medicine National Institutes of Health . Retrieved November 29, 2021, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066604/. 

Henry Ford Health System Staff. (2019, August 26). Less invasive aortic valve procedure approved for low-risk patients. Henry Ford LiveWell. Retrieved November 29, 2021, from https://www.henryford.com/blog/2019/08/less-invasive-aortic-valve-procedure-approved-low-risk-patients. 

Kornowski, R., & Landes, U. (2018, April 20). The double jeopardy of aortic stenosis in cancer patients . Academic.oup.com. Retrieved November 29, 2021, from https://academic.oup.com/ehjqcco/article/4/3/150/4979550. 

Landes, U., Iakobishvili, Z., & Vronsky, D. (2019, January 9). TAVR in cancer patients with severe AS. American College of Cardiology. Retrieved November 29, 2021, from https://www.acc.org/latest-in-cardiology/journal-scans/2019/01/09/14/19/transcatheter-aortic-valve-replacement-in-oncology-patients. 

Lind, A., Totzeck, M., Mahabadi, A. A., Jánosi, R. A., Gabry, M. E., Ruhparwar, A., Mrotzek, S. M., Hinrichs, L., Akdeniz, M., Rassaf, T., Mincu, R. I., C.E., D. S., Al., E., D., C., G.C., J., M., T., C., F., S.H., A., W.K., H., … B.R., L. (2020, December 2). Impact of cancer in patients undergoing transcatheter aortic valve replacement: A Single-Center Study. JACC. Retrieved November 29, 2021, from https://www.jacc.org/doi/10.1016/j.jaccao.2020.11.008. 

Lopez-Jimenez, F. (2021, February 19). Aortic calcification: an early sign of heart valve problems?Mayo Clinic. Retrieved November 29, 2021, from https://www.mayoclinic.org/diseases-conditions/aortic-stenosis/expert-answers/aortic-valve-calcification/faq-20058525. 

Marmagkiolis, K., Monlezun, D. J., Cilingiroglu, M., Grines, C., Herrmann, J., Toutouzas, K. P., Ates, I., & Iliescu, C. (2021, August 4). TAVR in cancer patients: Comprehensive review, meta-analysis, and meta-regression. Frontiers in Cardiovascular Medicine. Retrieved November 29, 2021, from https://www.frontiersin.org/articles/10.3389/fcvm.2021.641268/full. 


Anxiety and Spirituality During COVID-19

Emma Winfree

                                     Anxiety and Spirituality During COVID-19

 

            During the pandemic, I would think it is safe to say we all felt at least some anxiety about what was to come and what the future was going to look like. As a student, I was mainly concerned about myself and my family members staying healthy. Healthcare workers, on the other hand, had all of that to worry about, as well as keeping their patients healthy. A study was conducted in two different hospitals in Nigeria. These studies focused on the healthcare workers, about half of them being nurses. These health care workers were questioned, using a questionnaire, on their anxiety about the Coronavirus, as well as their socio-demographics and their spirituality and religiousness. I found this study intriguing after talking to many healthcare workers during the pandemic and their anxiety levels being at an all-time high. The pandemic took a toll on all healthcare workers, and still is. 

            The study was conducted on 92 males and 160 females. The median age of these participants was 40 years old. The two different hospitals were used as a cross-sectional study to show the differences in the anxiety levels of the spiritual workers versus the non-spiritual workers. According to the study, “spirituality is inversely correlated with anxiety among nurses and other non-heath workers” (Davis et al., 2003). The article talks about spirituality not only being a coping strategy in times of need, but it also being an “instinctive and inexpensive resource” to help improve their coping capacities. 

            In another study, it was found that spiritual well-being was a significant predictor of death anxiety (Rababa et al., 2021). Death anxiety usually occurs in older adults when they ultimately fear dying. Death anxiety hit an all-time high during the COVID-19 pandemic. This study insinuates that the more spiritual an individual is, the less death anxiety they will have. There is also a correlation between one’s sociodemographic, religious coping and lower levels of death anxiety.

 

Akanni, Oluyemi O., et al. “Relationship between Spirituality and Anxiety during the COVID-19 Pandemic: a Survey of the Staff of Two Nigerian Tertiary Hospitals.” Mental Health, Religion & Culture, vol. 24, no. 7, 2021, pp. 647–658., https://doi.org/10.1080/13674676.2020.1870218.

 

Rababa, Mohammad, et al. “Correction to: Association of Death Anxiety with Spiritual Well‑Being and Religious Coping in Older Adults During the COVID‑19 Pandemic.” Journal of Religion and Health, vol. 60, no. 1, 2021, pp. 64–64., https://doi.org/10.1007/s10943-021-01181-1.

Can COVID spread through lactation?



    At my job as a newborn hearing screener and sometimes the pediatrician comes into the room to talk to moms. A common question moms ask is whether their baby will be protected from COVID-19 if they have received the vaccine because they will breastfeed and pass on antibodies for it. Or, if they have COVID-19, can their baby get it if they breastfeed.
    Breastfeeding is always recommended if the mom is able, given its beneficial effects on the neonate’s development. Breastfeeding has been associated with a reduced risk of developing leukemia, asthma, and type 1 diabetes and has a role in developing the neonate’s cognitive abilities. Breastfeeding also positively affects maternal evolution, reducing the risk of developing breast or ovarian cancer postpartum. Breastfeeding has also been associated with decreased risk of postpartum depression among mothers (Florea, 2021). The considerable risk when breastfeeding is infectious diseases that could spread and infect the baby either by the milk or close contact between the mother and the infant.
    When SARS-CoV-2 first broke out, it was uncertain if the vertical transmission was possible through breast milk. Samples of breastmilk were taken from mothers with COVID-19, and there were 12 reported positive cases of SARS-CoV-2 RNA was found, but it is still unknown if viral particles were viable or not. Those samples that were to be positive for SARS-CoV-2 RNA were negative after a couple of days. Moreover, all the babies were repeatedly tested negative for SARS-CoV-2 (Florea, 2021). Vertical transmission through breast milk seems unlikely.
    One of the essential aspects of breastfeeding is that it can ​​pass on antibodies that protect the infant from many viruses, such as syncytial respiratory virus, influenza A virus, rotavirus, and SAR-CoV-2. Antibodies play a role in developing the immune system of neonates and be a measure of short-term protection against the virus—the existence of IgG and IgA anti-SARS-CoV-2-antibodies in breast milk (Florea, 2021). Although COVID-19 is a concern in infants, breastfeeding advantages outweigh the risk, and lactation was encouraged at least six months after being born.

Florea RM, Sultana CM. COVID-19 and breastfeeding: can SARS-CoV-2 be spread through
 lactation? Discoveries (Craiova). 2021 Jun 30;9(2):e132. doi: 10.15190/d.2021.11. PMID: 34754901; PMCID: PMC8570917.

Blue Light

Theoretically, blue-light-blocking glasses are supposed to help regulate your circadian rhythm. Claims have been made to reduce eye strain while using digital devices, especially in the evenings. In the past couple of years, it has been highly marketed for consumers. But does it truly have an effect, or is it just a marketing scheme?


In a study performed with over 100 participants, there was no significant difference in eye fatigue or improvement in eye-straining. There were also no observed differences in sleep quality. All the selling points of manufacturers of blue-light-blocking glasses are not supported by scientific evidence.


So why has there been such an interest in the effects of blue light? Blue light is the highest energy of visible light with the shortest wavelength. Sources of blue light include the sun, digital screens, LEDs, and fluorescent lightings. The amount of blue light can also profoundly affect our skin (look into blue light makeup, yes, it is a real thing). In high amounts, blue light emission on our skin can activate reactive oxygen species. This can be different from UV light as the blue light emission effect on skin pigmentation correlates more with opsin actions, a group of proteins that induce hyperpigmentation.


On the flip side, there have been some benefits to blue light emission as well. As part of photodynamic therapy, small doses of blue light emission have benefited those with actinic keratosis, Vulgaris psoriasis, eczema, acne vulgaris, and photorejuvenation. So before we altogether remove blue light and the question marks around it, it might not just be a marketing scheme, afterall. For your skin, at least.


Lawrenson, J. G., Hull, C. C., & Downie, L. E. (2017). The effect of blue-light blocking spectacle lenses on visual performance, macular health and the sleep-wake cycle: A systematic review of the literature. Ophthalmic and Physiological Optics37(6), 644–654. https://doi.org/10.1111/opo.12406

 

Coats, J. G., Maktabi, B., Abou‐Dahech, M. S., & Baki, G. (2021). Blue Light Protection, Part I—Effects of blue light on the skin. Journal of Cosmetic Dermatology20(3), 714–717. https://doi.org/10.1111/jocd.13837

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